CATH Classification

Domain Context

CATH Clusters

Superfamily Galactose-binding domain-like
Functional Family Exo-beta-D-glucosaminidase

Enzyme Information

3.2.1.165
Exo-1,4-beta-D-glucosaminidase.
based on mapping to UniProt Q56F26
Hydrolysis of chitosan or chitosan oligosaccharides to remove successive D-glucosamine residues from the non-reducing termini.
-!- Chitosan is a partially or totally N-deacetylated chitin derivative that is found in the cell walls of some phytopathogenic fungi and comprises D-glucosamine residues with a variable content of GlcNAc residues. -!- Acts specifically on chitooligosaccharides and chitosan, having maximal activity on chitotetraose, chitopentaose and their corresponding alcohols. -!- Can degrade GlcN-GlcNAc but not GlcNAc-GlcNAc.

UniProtKB Entries (1)

Q56F26
EBDG_AMYOR
Amycolatopsis orientalis
Exo-beta-D-glucosaminidase

PDB Structure

PDB 2VZR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Evidence that Family 35 Carbohydrate Binding Modules Display Conserved Specificity But Divergent Function.
Montanier, C., Van Bueren, A.L., Dumon, C., Flint, J.E., Correia, M.A., Prates, J.A., Firbank, S.J., Lewis, R.J., Grondin, G.G., Ghinet, M.G., Gloster, T.M., Herve, C., Knox, J.P., Talbot, B.G., Turkenburg, J.P., Kerovuo, J., Brzezinski, R., Fontes, C.M.G.A., Davies, G.J., Boraston, A.B., Gilbert, H.J.
Proc.Natl.Acad.Sci.USA