CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family p-hydroxycinnamoyl CoA hydratase/lyase

Enzyme Information

4.2.1.101
Trans-feruloyl-CoA hydratase.
based on mapping to UniProt O69762
4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA = feruloyl-CoA + H(2)O.
4.1.2.41
Vanillin synthase.
based on mapping to UniProt O69762
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = vanillin + acetyl- CoA.
-!- Involved, together with EC 4.2.1.101 in the production of vanillin from trans-ferulic acid. -!- Vanillin is converted to vanillate by EC 1.2.1.67.

UniProtKB Entries (1)

O69762
HCHL_PSEFL
Pseudomonas fluorescens
Hydroxycinnamoyl-CoA hydratase-lyase

PDB Structure

PDB 2VSU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Ternary Complex of Hydroxycinnamoyl-Coa Hydratase-Lyase (Hchl) with Acetyl-Coa and Vanillin Gives Insights Into Substrate Specificity and Mechanism.
Bennett, J.P., Bertin, L., Moulton, B., Fairlamb, I.J.S., Brzozowski, A.M., Walton, N.J., Grogan, G.
Biochem.J.