CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial

Enzyme Information

1.3.1.104
Enoyl-[acyl-carrier-protein] reductase.
based on mapping to UniProt Q9BV79
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADPH.
-!- The enzyme completes each cycle of fatty acid elongation by catalyzing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl- carrier protein, in an NADPH-dependent manner. -!- This entry stands for enzymes whose stereo-specificity with respect to NADP(+) is not known (cf. EC 1.3.1.39, EC 1.3.1.10 and EC 1.3.1.9).

UniProtKB Entries (1)

Q9BV79
MECR_HUMAN
Homo sapiens
Enoyl-[acyl-carrier-protein] reductase, mitochondrial

PDB Structure

PDB 2VCY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Enzymological Studies of 2-Enoyl Thioester Reductase of the Human Mitochondrial Fas II Pathway: New Insights Into its Substrate Recognition Properties.
Chen, Z.J., Pudas, R., Sharma, S., Smart, O.S., Juffer, A.H., Hiltunen, J.K., Wierenga, R.K., Haapalainen, A.M.
J.Mol.Biol.