CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.230.10
Functional Family

Enzyme Information

2.7.1.148
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase.
based on mapping to UniProt O67060
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
-!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

O67060
ISPE_AQUAE
Aquifex aeolicus VF5
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

PDB Structure

PDB 2V2Q
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase Ispe of the Non-Mevalonate Pathway for Isoprenoid Biosynthesis.
Crane, C.M., Hirsch, A.K., Alphey, M.S., Sgraja, T., Lauw, S., Illarionova, V., Rohdich, F., Eisenreich, W., Hunter, W.N., Bacher, A., Diederich, F.
Chemmedchem