CATH Classification

Domain Context

CATH Clusters

Superfamily Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family Rho guanine nucleotide exchange factor (GEF) 25

Enzyme Information

UniProtKB Entries (2)

P21279
GNAQ_MOUSE
Mus musculus
Guanine nucleotide-binding protein G(q) subunit alpha
Q86VW2
ARHGP_HUMAN
Homo sapiens
Rho guanine nucleotide exchange factor 25

PDB Structure

PDB 2RGN
External Links
Method X-RAY DIFFRACTION
Organism Trichoplusia
Primary Citation
Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Lutz, S., Shankaranarayanan, A., Coco, C., Ridilla, M., Nance, M.R., Vettel, C., Baltus, D., Evelyn, C.R., Neubig, R.R., Wieland, T., Tesmer, J.J.
Science