CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Serine/threonine protein kinase

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P9WI73
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P9WI73
PKNG_MYCTU
Mycobacterium tuberculosis H37Rv
Serine/threonine-protein kinase PknG

PDB Structure

PDB 2PZI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis.
Scherr, N., Honnappa, S., Kunz, G., Mueller, P., Jayachandran, R., Winkler, F., Pieters, J., Steinmetz, M.O.
Proc.Natl.Acad.Sci.Usa