CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate/ornithine carbamoyltransferase
Functional Family Ornithine carbamoyltransferase

Enzyme Information

2.1.3.3
Ornithine carbamoyltransferase.
based on mapping to UniProt P9WIT9
Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.
-!- The plant enzyme also catalyzes the reactions of EC 2.1.3.6, EC 2.7.2.2 and EC 3.5.3.12, thus acting as putrescine synthase, converting agmatine and ornithine into putrescine and citrulline respectively.

UniProtKB Entries (1)

P9WIT9
OTC_MYCTU
Mycobacterium tuberculosis H37Rv
Ornithine carbamoyltransferase

PDB Structure

PDB 2P2G
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism.
Sankaranarayanan, R., Cherney, M.M., Cherney, L.T., Garen, C.R., Moradian, F., James, M.N.
J.Mol.Biol.