CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family Beta-lactamase

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P00811
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P00811
AMPC_ECOLI
Escherichia coli K-12
Beta-lactamase

PDB Structure

PDB 2I72
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Optimizing Cell Permeation of an Antibiotic Resistance Inhibitor for Improved Efficacy
Venturelli, A., Tondi, D., Cancian, L., Morandi, F., Cannazza, G., Segatore, B., Prati, F., Amicosante, G., Shoichet, B.K., Costi, M.P.
J.Med.Chem.