CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase |
Enzyme Information
| 2.1.1.346 |
U6 snRNA m(6)A methyltransferase.
based on mapping to UniProt Q86W50
S-adenosyl-L-methionine + adenine in U6 snRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine in U6 snRNA.
-!- This enzyme, found in vertebrates, methylates a specific adenine in a hairpin structure of snRNA. -!- The effects of the binding of the methyltransferase to its substrate is important for the regulation of the activity of an isoform of EC 2.5.1.6, that produces S-adenosyl-L-methionine. -!- The enzyme also binds (and maybe methylates) the lncRNAs XIST and MALAT1 as well as a number of pre-mRNAs at specific positions often found in the intronic regions.
|
| 2.1.1.348 |
mRNA m(6)A methyltransferase.
based on mapping to UniProt Q86W50
S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine in mRNA.
-!- This enzyme, found in eukaryotes, methylates adenines in mRNA with the consensus sequence RRACH.
|
UniProtKB Entries (1)
| Q86W50 |
MET16_HUMAN
Homo sapiens
RNA N6-adenosine-methyltransferase METTL16
|
PDB Structure
| PDB | 2H00 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The Crystal Structure of Human methyltransferase 10 domain containing protein.
To be Published
|