CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.50.40
Functional Family chromodomain-helicase-DNA-binding protein 8 isoform X4

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt Q8TD26
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

Q8TD26
CHD6_HUMAN
Homo sapiens
Chromodomain-helicase-DNA-binding protein 6

PDB Structure

PDB 2EPB
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of chromo domain 2 in Chromodomain-helicase-DNA-binding protein 6
Tsuda, K., Muto, Y., Inoue, M., Kigawa, T., Terada, T., Shirouzu, M., Yokoyama, S.
To be Published