CATH Classification

Domain Context

CATH Clusters

Superfamily 2.30.30.100
Functional Family

Enzyme Information

6.3.4.15
Biotin--[biotin carboxyl-carrier protein] ligase.
based on mapping to UniProt Q59014
ATP + biotin + [biotin carboxyl-carrier protein]-L-lysine = AMP + diphosphate + [biotin carboxyl-carrier protein]-N(6)-biotinyl-L-lysine.
-!- The enzyme biotinylates a biotin carboxyl-carrier protein that is part of an acetyl-CoA carboxylase complex, enabling its subsequent carboxylation by EC 6.3.4.14. -!- The carboxyl group is eventually transferred to acetyl-CoA by EC 2.1.3.15. -!- In some organisms the carrier protein is part of EC 6.4.1.2.

UniProtKB Entries (1)

Q59014
BPL_METJA
Methanocaldococcus jannaschii DSM 2661
Putative biotin ligase

PDB Structure

PDB 2EJ9
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure Of Biotin Protein Ligase From Methanococcus jannaschii
Bagautdinov, B., Bagautdinova, S., Kunishima, N.
To be Published