CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.418 | Actin-binding Protein, T-fimbrin; domain 1 |
|
1.10.418.10 | Calponin-like domain |
Domain Context
CATH Clusters
| Superfamily | Calponin-like domain |
| Functional Family | protein-methionine sulfoxide oxidase MICAL3 isoform X1 |
Enzyme Information
| 1.14.13.225 |
F-actin monooxygenase.
based on mapping to UniProt O94851
[F-actin]-L-methionine + NADPH + O(2) + H(+) = [F-actin]-L-methionine- (R)-S-oxide + NADP(+) + H(2)O.
-!- The enzyme, characterized from the fruit fly Drosophila melanogaster, is a multi-domain oxidoreductase that acts as an F-actin disassembly factor. -!- The enzyme selectively reduces two L-Met residues of F-actin, causing fragmentation of the filaments and preventing repolymerization. -!- Free methionine is not a substrate. -!- The reaction is stereospecific and generates the (R)-sulfoxide.
|
UniProtKB Entries (1)
| O94851 |
MICA2_HUMAN
Homo sapiens
[F-actin]-monooxygenase MICAL2
|
PDB Structure
| PDB | 2E9K |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution structure of the CH domain from human MICAL-2
To be Published
|