CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Dihydroorotate dehydrogenase A (fumarate)

Enzyme Information

1.3.98.1
Dihydroorotate oxidase (fumarate).
based on mapping to UniProt A2RJT9
(S)-dihydroorotate + fumarate = orotate + succinate.
-!- The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. -!- Molecular oxygen can replace fumarate in vitro. -!- Other class 1 dihydroorotate dehydrogenases use either NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor. -!- Formerly EC 1.3.3.1.

UniProtKB Entries (1)

A2RJT9
PYRDA_LACLM
Lactococcus lactis subsp. cremoris MG1363
Dihydroorotate dehydrogenase A (fumarate)

PDB Structure

PDB 2DOR
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function.
Rowland, P., Bjornberg, O., Nielsen, F.S., Jensen, K.F., Larsen, S.
Protein Sci.