CATH Classification

Domain Context

CATH Clusters

Superfamily Copper amine oxidase, catalytic domain
Functional Family Amine oxidase

Enzyme Information

1.4.3.21
Primary-amine oxidase.
based on mapping to UniProt P46881
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.

UniProtKB Entries (1)

P46881
PAOX_ARTGO
Arthrobacter globiformis
Phenylethylamine oxidase

PDB Structure

PDB 2CFG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Enantiomer-Specific Binding of Ruthenium(II) Molecular Wires by the Amine Oxidase of Arthrobacter Globiformis.
Langley, D.B., Brown, D.E., Cheruzel, L.E., Contakes, S.M., Duff, A.P., Hilmer, K.M., Dooley, D.M., Gray, H.B., Guss, J.M., Freeman, H.C.
J.Am.Chem.Soc.