CATH Classification

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family mRNA-capping enzyme

Enzyme Information

3.1.3.33
Polynucleotide 5'-phosphatase.
based on mapping to UniProt O60942
A 5'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate.
-!- Does not act on nucleoside monophosphates. -!- Induced in Escherichia coli by T-even phages.
2.7.7.50
mRNA guanylyltransferase.
based on mapping to UniProt O60942
GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA.
-!- Can modify also synthetic poly(A) and poly(G) to form the structures m(7)G(5')pppAn and m(7)G(5')pppGn.

UniProtKB Entries (1)

O60942
MCE1_HUMAN
Homo sapiens
MRNA-capping enzyme

PDB Structure

PDB 2C46
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Human RNA Guanylyltransferase and 5'-Phosphatase
Debreczeni, J., Johansson, C., Longman, E., Gileadi, O., Savitskysmee, P., Smee, C., Bunkoczi, G., Ugochukwu, E., von Delft, F., Sundstrom, M., Weigelt, J., Arrowsmith, C., Edwards, A., Knapp, S.
To be Published