CATH Classification

Domain Context

CATH Clusters

Superfamily Calcium-transporting ATPase, cytoplasmic domain N
Functional Family ATPase copper transporting beta

Enzyme Information

7.2.2.8
P-type Cu(+) transporter.
based on mapping to UniProt P35670
ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2).
-!- A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- This enzyme transports Cu(+) or Ag(+), and cannot transport the divalent ions, contrary to EC 7.2.2.9, which mainly transports the divalent copper ion. -!- Formerly EC 3.6.3.54.

UniProtKB Entries (1)

P35670
ATP7B_HUMAN
Homo sapiens
Copper-transporting ATPase 2

PDB Structure

PDB 2ARF
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Solution structure of the N-domain of Wilson disease protein: Distinct nucleotide-binding environment and effects of disease mutations
Dmitriev, O., Tsivkovskii, R., Abildgaard, F., Morgan, C.T., Markley, J.L., Lutsenko, S.
Proc.Natl.Acad.Sci.Usa