CATH Classification

Domain Context

CATH Clusters

Superfamily Histidine kinase-like ATPase, C-terminal domain
Functional Family Mitochondrial pyruvate dehydrogenase kinase isoform 2

Enzyme Information

2.7.11.2
[Pyruvate dehydrogenase (acetyl-transferring)] kinase.
based on mapping to UniProt Q15120
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.
-!- Has no activating compound but is specific for its substrate. -!- A mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. -!- Phosphorylation inactivates EC 1.2.4.1. -!- Formerly EC 2.7.1.99.

UniProtKB Entries (1)

P10515
ODP2_HUMAN
Homo sapiens
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

PDB Structure

PDB 1Y8N
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex.
Kato, M., Chuang, J.L., Tso, S.C., Wynn, R.M., Chuang, D.T.
Embo J.