CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family

Enzyme Information

3.4.11.5
Prolyl aminopeptidase.
based on mapping to UniProt P96084
Release of N-terminal proline from a peptide.
-!- Present in the cytosol of mammalian and microbial cells. -!- In contrast to the mammalian form, the bacterial form of the enzyme hydrolyzes both polyproline and prolyl-2-naphthylamide. -!- The mammalian enzyme, which is not specific for prolyl bonds, is possibly identical with EC 3.4.11.1. -!- Belongs to peptidase family S33. -!- Formerly EC 3.4.1.4.

UniProtKB Entries (1)

P96084
PIP_THEAC
Thermoplasma acidophilum DSM 1728
Proline iminopeptidase

PDB Structure

PDB 1XQX
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
X-ray snapshots of peptide processing in mutants of tricorn-interacting factor F1 from Thermoplasma acidophilum
Goettig, P., Brandstetter, H., Groll, M., Goehring, W., Konarev, P.V., Svergun, D.I., Huber, R., Kim, J.-S.
J.Biol.Chem.