CATH Classification

Domain Context

CATH Clusters

Superfamily DHBP synthase
Functional Family 3,4-dihydroxy-2-butanone 4-phosphate synthase

Enzyme Information

4.1.99.12
3,4-dihydroxy-2-butanone-4-phosphate synthase.
based on mapping to UniProt Q5A3V6
D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.
-!- The reaction involves an intramolecular skeletal rearrangement, with the bonds in D-ribulose 5-phosphate that connect C-3 and C-5 to C-4 being broken, C-4 being removed as formate and reconnection of C-3 and C-5. -!- The phosphorylated four-carbon product (L-3,4-dihydroxybutan-2-one 4-phosphate) is an intermediate in the biosynthesis of riboflavin.

UniProtKB Entries (1)

Q5A3V6
RIB3_CANAL
Candida albicans SC5314
3,4-dihydroxy-2-butanone 4-phosphate synthase

PDB Structure

PDB 1TKS
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans.
Echt, S., Bauer, S., Steinbacher, S., Huber, R., Bacher, A., Fischer, M.
J.Mol.Biol.