CATH Classification

Domain Context

CATH Clusters

Superfamily Aldehyde Dehydrogenase; Chain A, domain 2
Functional Family Methylmalonate-semialdehyde dehydrogenase (Acylating)

Enzyme Information
Methylmalonate-semialdehyde dehydrogenase (CoA acylating).
based on mapping to UniProt P42412
2-methyl-3-oxopropanoate + CoA + H(2)O + NAD(+) = propanoyl-CoA + HCO(3)(-) + NADH.
-!- Also converts 3-oxopropanoate into acetyl-CoA. -!- The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. -!- Bicarbonate rather than CO(2) is released as a final product.
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt P42412

UniProtKB Entries (1)

Bacillus subtilis subsp. subtilis str. 168
Malonate-semialdehyde dehydrogenase

PDB Structure

PDB 1T90
External Links
Organism Escherichia
Primary Citation
Crystal structure analysis of Methylmalonate-Semialdehyde Dehydrogenase from Bacillus subtilis.
Dubourg, H., Didierjean, C., Stines-Chaumeil, C., Talfournier, F., Branlant, G., Aubry, A., Corbier, C.
To be published