CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.605 | Aldehyde Dehydrogenase; Chain A, domain 1 |
|
3.40.605.10 | Aldehyde Dehydrogenase; Chain A, domain 1 |
Domain Context
CATH Clusters
| Superfamily | Aldehyde Dehydrogenase; Chain A, domain 1 |
| Functional Family | Methylmalonate-semialdehyde dehydrogenase [acylating] |
Enzyme Information
| 1.2.1.27 |
Methylmalonate-semialdehyde dehydrogenase (CoA acylating).
based on mapping to UniProt P42412
2-methyl-3-oxopropanoate + CoA + H(2)O + NAD(+) = propanoyl-CoA + HCO(3)(-) + NADH.
-!- Also converts 3-oxopropanoate into acetyl-CoA. -!- The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. -!- Bicarbonate rather than CO(2) is released as a final product.
|
| 1.2.1.- |
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt P42412
|
UniProtKB Entries (1)
| P42412 |
IOLA_BACSU
Bacillus subtilis subsp. subtilis str. 168
Malonate-semialdehyde dehydrogenase
|
PDB Structure
| PDB | 1T90 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure analysis of Methylmalonate-Semialdehyde Dehydrogenase from Bacillus subtilis.
To be published
|