CATH Classification

Domain Context

CATH Clusters

Superfamily Fumarase/aspartase (N-terminal domain)
Functional Family

Enzyme Information

4.3.1.25
Phenylalanine/tyrosine ammonia-lyase.
based on mapping to UniProt P11544
(1) L-phenylalanine = trans-cinnamate + ammonia. (2) L-tyrosine = trans-p-hydroxycinnamate + ammonia.
-!- Member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3, EC 4.3.1.23 and EC 4.3.1.24. -!- The enzyme from some monocots, including maize, and from the yeast Rhodosporidium toruloides, deaminate L-phenylalanine and L-tyrosine with similar catalytic efficiency. -!- Formerly EC 4.3.1.5.

UniProtKB Entries (1)

P11544
PALY_RHOTO
Rhodotorula toruloides
Phenylalanine/tyrosine ammonia-lyase

PDB Structure

PDB 1T6J
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
Calabrese, J.C., Jordan, D.B., Boodhoo, A., Sariaslani, S., Vannelli, T.
Biochemistry