CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family UDP-sulfoquinovose synthase, chloroplastic

Enzyme Information

3.13.1.1
UDP-sulfoquinovose synthase.
based on mapping to UniProt O48917
UDP-alpha-D-sulfoquinovose + H(2)O = UDP-alpha-D-glucose + sulfite.
-!- NAD(+) appears to oxidize the substrate to UDP-4-dehydroglucose, which dehydrates to UDP-4-dehydro-6-deoxygluc-5-enose, to which sulfite can add; the reaction is completed when the substrate is rehydrogenated at C-4. -!- The enzyme from Arabidopsis thaliana is specific for UDP-Glc and sulfite.

UniProtKB Entries (1)

O48917
SQD1_ARATH
Arabidopsis thaliana
UDP-sulfoquinovose synthase, chloroplastic

PDB Structure

PDB 1QRR
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of SQD1, an enzyme involved in the biosynthesis of the plant sulfolipid headgroup donor UDP-sulfoquinovose.
Mulichak, A.M., Theisen, M.J., Essigmann, B., Benning, C., Garavito, R.M.
Proc.Natl.Acad.Sci.USA