CATH Classification

Domain Context

CATH Clusters

Superfamily Isopropylmalate Dehydrogenase
Functional Family 4-hydroxythreonine-4-phosphate dehydrogenase

Enzyme Information

1.1.1.262
4-hydroxythreonine-4-phosphate dehydrogenase.
based on mapping to UniProt P19624
4-phosphooxy-L-threonine + NAD(+) = 3-amino-2-oxopropyl phosphate + CO(2) + NADH.
-!- The enzyme is part of the biosynthesis pathway of the coenzyme pyridoxal 5'-phosphate found in anaerobic bacteria.

UniProtKB Entries (1)

P19624
PDXA_ECOLI
Escherichia coli K-12
4-hydroxythreonine-4-phosphate dehydrogenase

PDB Structure

PDB 1PS7
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of Escherichia coli PdxA, an Enzyme Involved in the Pyridoxal Phosphate Biosynthesis Pathway
Sivaraman, J., Li, Y., Banks, J., Cane, D.E., Matte, A., Cygler, M.
J.Biol.Chem.