CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Functional Family Thymidine phosphorylase

Enzyme Information

2.4.2.4
Thymidine phosphorylase.
based on mapping to UniProt P07650
Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.
-!- In some tissues also catalyzes deoxyribosyltransferase reactions of the type catalyzed by EC 2.4.2.6. -!- Formerly EC 2.4.2.23.

UniProtKB Entries (1)

P07650
TYPH_ECOLI
Escherichia coli K-12
Thymidine phosphorylase

PDB Structure

PDB 1OTP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase.
Pugmire, M.J., Cook, W.J., Jasanoff, A., Walter, M.R., Ealick, S.E.
J.Mol.Biol.