CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.160.20
Functional Family Ribonuclease 3

Enzyme Information

3.1.26.3
Ribonuclease III.
based on mapping to UniProt Q9X0I6
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- An endoribonuclease that cleaves double-stranded RNA molecules. -!- The cleavage can be either a single-stranded nick or double-stranded break in the RNA, depending in part upon the degree of base-pairing in the region of the cleavage site. -!- Specificity is conferred by negative determinants, i.e., the presence of certain Watson-Crick base-pairs at specific positions that strongly inhibit cleavage. -!- RNase III is involved in both rRNA processing and mRNA processing and decay.

UniProtKB Entries (1)

Q9X0I6
RNC_THEMA
Thermotoga maritima MSB8
Ribonuclease 3

PDB Structure

PDB 1O0W
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of Ribonuclease III (TM1102) from Thermotoga maritima at 2.0 A resolution
Joint Center for Structural Genomics (JCSG)
To be published