CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside phosphorylase domain
Functional Family Purine nucleoside phosphorylase

Enzyme Information

6.3.2.1
Pantoate--beta-alanine ligase (AMP-forming).
based on mapping to UniProt P9WIL5
ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.

UniProtKB Entries (1)

P9WIL5
PANC_MYCTU
Mycobacterium tuberculosis H37Rv
Pantothenate synthetase

PDB Structure

PDB 1N3I
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Over-The-Barrier Transition State Analogues Provide New Chemistries for Inhibitor Design: The Case of Purine Nucleoside Phosphorylase
Lewandowicz, A., Shi, W., Evans, G.B., Tyler, P.C., Furneaux, R.H., Basso, L.A., Santos, D.S., Almo, S.C., Schramm, V.L.
BIOCHEMISTRY