CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family Glutathione S-transferase S1

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt P41043
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

P41043
GSTS1_DROME
Drosophila melanogaster
Glutathione S-transferase S1

PDB Structure

PDB 1M0U
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of a Drosophila Sigma Class Glutathione S-transferase Reveals a Novel Active Site Topography Suited for Lipid Peroxidation Products
Agianian, B., Tucker, P.A., Schouten, A., Leonard, K., Bullard, B., Gros, P.
J.Mol.Biol.