CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

Enzyme Information

1.1.1.35
3-hydroxyacyl-CoA dehydrogenase.
based on mapping to UniProt Q16836
(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
-!- Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate. -!- Some enzymes act, more slowly, with NADP(+). -!- Broad specificity to acyl chain-length (cf. EC 1.1.1.211).

UniProtKB Entries (1)

Q16836
HCDH_HUMAN
Homo sapiens
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

PDB Structure

PDB 1LSJ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of the E110Q Mutant of L-3-Hydroxyacyl-CoA Dehydrogenase in Complex with NAD
Barycki, J.J., Banaszak, L.J.
To be Published