CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.450.60
Functional Family Arachidonate 12-lipoxygenase, 12S-type

Enzyme Information

1.13.11.33
Arachidonate 15-lipoxygenase.
based on mapping to UniProt P12530
Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa- 5,8,11,13-tetraenoate.
-!- The product is rapidly converted to the corresponding 15S-hydroxy compound.
1.13.11.31
Arachidonate 12-lipoxygenase.
based on mapping to UniProt P12530
Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa- 5,8,10,14-tetraenoate.
-!- The product is rapidly reduced to the corresponding 12S-hydroxy compound.

UniProtKB Entries (1)

P12530
LOX15_RABIT
Oryctolagus cuniculus
Arachidonate 15-lipoxygenase

PDB Structure

PDB 1LOX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity.
Gillmor, S.A., Villasenor, A., Fletterick, R., Sigal, E., Browner, M.F.
Nat.Struct.Biol.