CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1190.20
Functional Family

Enzyme Information

2.7.1.147
ADP-specific glucokinase.
based on mapping to UniProt O58328
ADP + D-glucose = AMP + D-glucose 6-phosphate.
-!- The enzyme from Pyrococcus furiosus is highly specific for D-glucose; there is some activity with 2-deoxy-D-glucose, but no activity with D-fructose, D-mannose or D-galactose as the substrate. -!- No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate.

UniProtKB Entries (1)

O58328
GLKA_PYRHO
Pyrococcus horikoshii OT3
ADP-dependent glucokinase

PDB Structure

PDB 1L2L
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the ADP-dependent glucokinase from Pyrococcus horikoshii at 2.0-A resolution: a large conformational change in ADP-dependent glucokinase
Tsuge, H., Sakuraba, H., Kobe, T., Kujime, A., Katunuma, N., Ohshima, T.
PROTEIN SCI.