CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family Thymidylate synthase

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P0A884
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P0A884
TYSY_ECOLI
Escherichia coli K-12
Thymidylate synthase

PDB Structure

PDB 1KZI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access.
Fritz, T.A., Liu, L., Finer-Moore, J.S., Stroud, R.M.
Biochemistry