CATH Classification

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family

Enzyme Information

2.4.1.19
Cyclomaltodextrin glucanotransferase.
based on mapping to UniProt P43379
Cyclizes part of a (1->4)-alpha-D-glucan chain by formation of a (1->4)- alpha-D-glucosidic bond.
-!- Cyclomaltodextrins (Schardinger dextrins) of various sizes (6, 7, 8, etc. glucose units) are formed reversibly from starch and similar substrates. -!- Also disproportionates linear maltodextrins without cyclizing (cf. EC 2.4.1.25).

UniProtKB Entries (1)

P43379
CDGT2_BACCI
Bacillus circulans
Cyclomaltodextrin glucanotransferase

PDB Structure

PDB 1KCK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The remote substrate binding subsite -6 in cyclodextrin-glycosyltransferase controls the transferase activity of the enzyme via an induced-fit mechanism.
Leemhuis, H., Uitdehaag, J.C., Rozeboom, H.J., Dijkstra, B.W., Dijkhuizen, L.
J.Biol.Chem.