CATH Classification

Domain Context

CATH Clusters

Superfamily Hotdog Thioesterase
Functional Family MaoC domain protein dehydratase

Enzyme Information

4.2.1.119
Enoyl-CoA hydratase 2.
based on mapping to UniProt O32472
(3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H(2)O.
-!- This enzyme catalyzes a hydration step in peroxisomal beta-oxidation. -!- The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme composed of three functional units: (3R)-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein 2-like units. -!- The enzymes from Aeromonas caviae and Arabidopsis thaliana are monofunctional enzymes. -!- 2-enoyl-CoA hydratase 3 from Candida tropicalis is a part from multifunctional enzyme type 2.

UniProtKB Entries (1)

O32472
PHAJ_AERCA
Aeromonas caviae
(R)-specific enoyl-CoA hydratase

PDB Structure

PDB 1IQ6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the (R)-specific enoyl-CoA hydratase from Aeromonas caviae involved in polyhydroxyalkanoate biosynthesis
Hisano, T., Tsuge, T., Fukui, T., Iwata, T., Miki, K., Doi, Y.
J.Biol.Chem.