CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.450.60
Functional Family Lipoxygenase

Enzyme Information

1.13.11.58
Linoleate 9S-lipoxygenase.
based on mapping to UniProt P09186
Linoleate + O(2) = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.
-!- A common plant lipoxygenase that oxidizes linoleate and alpha- linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C(9) position with (S)- configuration. -!- The enzyme plays a physiological role during the early stages of seedling growth. -!- The enzyme from Arabidopsis thaliana shows comparable activity toward linoleate and linolenate. -!- EC 1.13.11.12 catalyzes a similar reaction at another position of these fatty acids.

UniProtKB Entries (1)

P09186
LOX3_SOYBN
Glycine max
Seed linoleate 9S-lipoxygenase-3

PDB Structure

PDB 1HU9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of curcumin in complex with lipoxygenase and its significance in cancer.
Skrzypczak-Jankun, E., Zhou, K., McCabe, N.P., Selman, S.H., Jankun, J.
INT.J.MOL.MED.