CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Myo-inositol-1-phosphate synthase Ino1

Enzyme Information

5.5.1.4
Inositol-3-phosphate synthase.
based on mapping to UniProt P9WKI1
D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate.
-!- The NAD(+) dehydrogenates the -CHOH- group to -CO- at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the -CHO at C-1; finally, the enzyme-bound NADH reconverts C-5 into the -CHOH- form.

UniProtKB Entries (1)

P9WKI1
INO1_MYCTU
Mycobacterium tuberculosis H37Rv
Inositol-3-phosphate synthase

PDB Structure

PDB 1GR0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Inositol 1-Phosphate Synthase from Mycobacterium Tuberculosis, a Key Enzyme in Phosphatidylinositol Synthesis
Norman, R.A., Mcalister, M.S.B., Murray-Rust, J., Movahedzadeh, F., Stoker, N.G., Mcdonald, N.Q.
Structure