CATH Classification

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family Cyclin-dependent kinase inhibitor 3

Enzyme Information

3.1.3.16
Protein-serine/threonine phosphatase.
based on mapping to UniProt Q16667
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).
3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt Q16667
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P24941
CDK2_HUMAN
Homo sapiens
Cyclin-dependent kinase 2

PDB Structure

PDB 1FQ1
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2.
Song, H., Hanlon, N., Brown, N.R., Noble, M.E., Johnson, L.N., Barford, D.
Mol.Cell