CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome c oxidase-like, subunit I domain
Functional Family Cytochrome o ubiquinol oxidase, subunit I

Enzyme Information

7.1.1.3
Ubiquinol oxidase (H(+)-transporting).
based on mapping to UniProt P0ABI8
2 ubiquinol + O(2) + n H(+)(Side 1) = 2 ubiquinone + 2 H(2)O + n H(+)(Side 2).
-!- This terminal oxidase enzyme generates proton motive force by two mechanisms: (1) transmembrane charge separation resulting from utilizing protons and electrons originating from opposite sides of the membrane to generate water, and (2) active pumping of protons across the membrane. -!- The bioenergetic efficiency (the number of charges driven across the membrane per electron used to reduce oxygen to water) depends on the enzyme; for example, for the bo(3) oxidase it is 2, while for the bd-II oxidase it is 1. -!- Cf. EC 7.1.1.7. -!- Formerly EC 1.10.3.10.

UniProtKB Entries (1)

P0ABI8
CYOB_ECOLI
Escherichia coli K-12
Cytochrome bo(3) ubiquinol oxidase subunit 1

PDB Structure

PDB 1FFT
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site.
Abramson, J., Riistama, S., Larsson, G., Jasaitis, A., Svensson-Ek, M., Laakkonen, L., Puustinen, A., Iwata, S., Wikstrom, M.
Nat.Struct.Biol.