CATH Classification

Domain Context

CATH Clusters

Superfamily Eco RI Endonuclease, subunit A
Functional Family

Enzyme Information

3.1.21.4
Type II site-specific deoxyribonuclease.
based on mapping to UniProt P00642
Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.
-!- Large group of enzymes which recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition site. -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/

UniProtKB Entries (1)

P00642
T2E1_ECOLX
Escherichia coli
Type-2 restriction enzyme EcoRI

PDB Structure

PDB 1ERI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Refinement of Eco RI endonuclease crystal structure: a revised protein chain tracing.
Kim, Y.C., Grable, J.C., Love, R., Greene, P.J., Rosenberg, J.M.
Science