CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Prolyl endopeptidase

Enzyme Information

3.4.21.26
Prolyl oligopeptidase.
based on mapping to UniProt P23687
Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.
-!- Found in vertebrates, plants and Flavobacterium. -!- Generally cytosolic, commonly activated by thiol compounds. -!- Belongs to peptidase family S9A. -!- Formerly EC 3.4.22.18.

UniProtKB Entries (1)

P23687
PPCE_PIG
Sus scrofa
Prolyl endopeptidase

PDB Structure

PDB 1E5T
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Catalysis of Serine Oligopeptidases is Controlled by a Gating Filter Mechanism
Fulop, V., Szeltner, Z., Polgar, L.
Embo Rep.