CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family Glutathione reductase, mitochondrial

Enzyme Information

1.8.1.7
Glutathione-disulfide reductase.
based on mapping to UniProt P00390
2 glutathione + NADP(+) = glutathione disulfide + NADPH.
-!- Activity is dependent on a redox-active disulfide in each of the active centers. -!- Formerly EC 1.6.4.2.

UniProtKB Entries (1)

P00390
GSHR_HUMAN
Homo sapiens
Glutathione reductase, mitochondrial

PDB Structure

PDB 1BWC
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies.
Gallwitz, H., Bonse, S., Martinez-Cruz, A., Schlichting, I., Schumacher, K., Krauth-Siegel, R.L.
J.Med.Chem.