CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Anionic trypsin

Enzyme Information

3.4.21.4
Trypsin.
based on mapping to UniProt P00763
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
-!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.4.

UniProtKB Entries (1)

P00763
TRY2_RAT
Rattus norvegicus
Anionic trypsin-2

PDB Structure

PDB 1BRA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Relocating a negative charge in the binding pocket of trypsin.
Perona, J.J., Tsu, C.A., McGrath, M.E., Craik, C.S., Fletterick, R.J.
J.Mol.Biol.