CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family S-(hydroxymethyl)glutathione dehydrogenase

Enzyme Information

1.1.1.1
Alcohol dehydrogenase.
based on mapping to UniProt P00327
(1) A primary alcohol + NAD(+) = an aldehyde + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
-!- Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. -!- The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.

UniProtKB Entries (1)

P00327
ADH1E_HORSE
Equus caballus
Alcohol dehydrogenase E chain

PDB Structure

PDB 1AXG
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A link between protein structure and enzyme catalyzed hydrogen tunneling.
Bahnson, B.J., Colby, T.D., Chin, J.K., Goldstein, B.M., Klinman, J.P.
Proc.Natl.Acad.Sci.USA