CATH Classification

Domain Context

CATH Clusters

Superfamily SH3 Domains
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P00520
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00520
ABL1_MOUSE
Mus musculus
Tyrosine-protein kinase ABL1

PDB Structure

PDB 1ABO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.
Musacchio, A., Saraste, M., Wilmanns, M.
Nat.Struct.Biol.