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CATH Superfamily 3.90.440.10

Nitric Oxide Synthase;Heme Domain;Chain A domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Nitric Oxide Synthase;Heme Domain;Chain A domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 232: Nitric oxide synthase, endothelial

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Nitric-oxide synthase (NADPH). [EC: 1.14.13.39]
2 L-arginine + 3 NADPH + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O.
  • This eukaryotic enzyme, which is found in plants and animals, consists of oxygenase and reductase domains that are linked via a regulatory calmodulin-binding domain.
  • Upon calcium-induced calmodulin binding, the reductase and oxygenase domains form a complex, allowing electrons to flow from NADPH via FAD and FMN to the active center.
  • May produce superoxide under certain conditions.
  • Cf. EC 1.14.13.165.
 217 A0A026VVR0 A0A034WK14 A0A034WS92 A0A061HW79 A0A061HXD8 A0A061I0G1 A0A061I2M7 A0A087YBB9 A0A089Q756 A0A090N8H8
(207 more...)
Nitric-oxide synthase (NAD(P)H). [EC: 1.14.13.165]
2 L-arginine + 3 NAD(P)H + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 NAD(P)(+) + 4 H(2)O.
  • Most of the bacterial and archaeal enzymes consist of only an oxidase domain and function together with bacterial ferredoxins.
  • The enzyme from the delta-proteobacterium Sorangium cellulosum also includes a reductase domain that binds FAD, FMN and a [2Fe-2S] cluster.
  • The similar enzymes from plants and animals use only NADPH as acceptor (cf. EC 1.14.13.39).
 25 A0A098S6N0 A0A0A3I4H5 A0A0B0QP43 A0A0B5APF7 A0A0B6AF34 A0A0C2VE38 A0A0C2W3X7 A0A0M0WAE8 A0A0Q6I9W2 A0A161J5D4
(15 more...)