# STOCKHOLM 1.0
#=GF ID 3.80.10.10/FF/2916
#=GF DE Volume-regulated anion channel subunit LRRC8D
#=GF AC 3.80.10.10/FF/2916
#=GF TP FunFam
#=GF DR CATH: 4.2
#=GF DR DOPS: 62.317
#=GS Q7L1W4/631-832      AC Q7L1W4
#=GS Q7L1W4/631-832      OS Homo sapiens
#=GS Q7L1W4/631-832      DE Volume-regulated anion channel subunit LRRC8D
#=GS Q7L1W4/631-832      DR GENE3D; 0db8750f39da16555182e1ff47979dd7/631-832; 
#=GS Q7L1W4/631-832      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; 
#=GS Q7L1W4/631-832      DR GO; GO:0005225; GO:0005515; GO:0005737; GO:0005886; GO:0005887; GO:0016020; GO:0055085; GO:0098656; 
#=GS Q5U308/631-839      AC Q5U308
#=GS Q5U308/631-839      OS Rattus norvegicus
#=GS Q5U308/631-839      DE Volume-regulated anion channel subunit LRRC8D
#=GS Q5U308/631-839      DR GENE3D; c3a935e43c97a55447c1fb4df9f6167a/631-839; 
#=GS Q5U308/631-839      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Rodentia; Myomorpha; Muridae; Murinae; Rattus; Rattus norvegicus; 
#=GS Q5U308/631-839      DR GO; GO:0005225; GO:0005737; GO:0005886; GO:0005887; GO:0098656; 
#=GS F7GUR8/631-832      AC F7GUR8
#=GS F7GUR8/631-832      OS Callithrix jacchus
#=GS F7GUR8/631-832      DE Leucine-rich repeat-containing protein 8D
#=GS F7GUR8/631-832      DR GENE3D; 0888ea384765527bab5b3bec496e600e/631-832; 
#=GS F7GUR8/631-832      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix; Callithrix jacchus; 
#=GS H2LAC6/586-711      AC H2LAC6
#=GS H2LAC6/586-711      OS Oryzias latipes
#=GS H2LAC6/586-711      DE Uncharacterized protein
#=GS H2LAC6/586-711      DR GENE3D; 0c1c1654977f1000bbfa43480beeeccd/586-711; 
#=GS H2LAC6/586-711      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Atherinomorphae; Beloniformes; Adrianichthyoidei; Adrianichthyidae; Oryziinae; Oryzias; Oryzias latipes; 
#=GS T1DB05/631-843      AC T1DB05
#=GS T1DB05/631-843      OS Crotalus horridus
#=GS T1DB05/631-843      DE Leucine-rich repeat-containing protein 8D-like protein
#=GS T1DB05/631-843      DR GENE3D; 1a2daeb0cc30540ba9fcf551ce6d0224/631-843; 
#=GS T1DB05/631-843      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Lepidosauria; Squamata; Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus; Crotalus horridus; 
#=GS J3SCJ6/631-843      AC J3SCJ6
#=GS J3SCJ6/631-843      OS Crotalus adamanteus
#=GS J3SCJ6/631-843      DE Leucine-rich repeat-containing protein 8D-like
#=GS J3SCJ6/631-843      DR GENE3D; 1a2daeb0cc30540ba9fcf551ce6d0224/631-843; 
#=GS J3SCJ6/631-843      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Lepidosauria; Squamata; Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus; Crotalus adamanteus; 
#=GS W5U703/545-737      AC W5U703
#=GS W5U703/545-737      OS Ictalurus punctatus
#=GS W5U703/545-737      DE Leucine-rich repeat-containing protein 8D
#=GS W5U703/545-737      DR GENE3D; 2465ecf76d7f6d21c9a03ab0b5ae1f5d/545-737; 
#=GS W5U703/545-737      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Characiphysae; Siluriformes; Siluroidei; Ictaluridae; Ictalurus; Ictalurus punctatus; 
#=GS W5LU14/589-731      AC W5LU14
#=GS W5LU14/589-731      OS Astyanax mexicanus
#=GS W5LU14/589-731      DE Uncharacterized protein
#=GS W5LU14/589-731      DR GENE3D; 2531a4688726a293236cb0359a058cea/589-731; 
#=GS W5LU14/589-731      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Characiphysae; Characiformes; Characoidei; Characidae; Astyanax; Astyanax mexicanus; 
#=GS A0A0H2UHA3/633-841  AC A0A0H2UHA3
#=GS A0A0H2UHA3/633-841  OS Rattus norvegicus
#=GS A0A0H2UHA3/633-841  DE Volume-regulated anion channel subunit LRRC8D
#=GS A0A0H2UHA3/633-841  DR GENE3D; 29bbc68b66a10e965b19521c95c88675/633-841; 
#=GS A0A0H2UHA3/633-841  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Rodentia; Myomorpha; Muridae; Murinae; Rattus; Rattus norvegicus; 
#=GS F6Z951/598-731      AC F6Z951
#=GS F6Z951/598-731      OS Equus caballus
#=GS F6Z951/598-731      DE Uncharacterized protein
#=GS F6Z951/598-731      DR GENE3D; 3962df22c2d431751a22a40cec800ea2/598-731; 
#=GS F6Z951/598-731      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Laurasiatheria; Perissodactyla; Equidae; Equus; Equus; Equus caballus; 
#=GS G1KUQ0/633-847      AC G1KUQ0
#=GS G1KUQ0/633-847      OS Anolis carolinensis
#=GS G1KUQ0/633-847      DE Uncharacterized protein
#=GS G1KUQ0/633-847      DR GENE3D; 3fb3a9236c8ca5cbbe2c6335863e0443/633-847; 
#=GS G1KUQ0/633-847      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Lepidosauria; Squamata; Iguania; Iguanidae; Polychrotinae; Anolis; Anolis carolinensis; 
#=GS L5K4Q3/669-868      AC L5K4Q3
#=GS L5K4Q3/669-868      OS Pteropus alecto
#=GS L5K4Q3/669-868      DE Leucine-rich repeat-containing protein 8D
#=GS L5K4Q3/669-868      DR GENE3D; 4d3701366c4ecd6a3efbc86105dbea91/669-868; 
#=GS L5K4Q3/669-868      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae; Pteropodinae; Pteropus; Pteropus alecto; 
#=GS A0A091IFX2/621-736  AC A0A091IFX2
#=GS A0A091IFX2/621-736  OS Calypte anna
#=GS A0A091IFX2/621-736  DE Leucine-rich repeat-containing protein 8D
#=GS A0A091IFX2/621-736  DR GENE3D; 7d44bfa69c3f931b5400ef2c02e8350c/621-736; 
#=GS A0A091IFX2/621-736  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Aves; Neognathae; Trochiliformes; Trochilidae; Calypte; Calypte anna; 
#=GS M4B034/557-720      AC M4B034
#=GS M4B034/557-720      OS Xiphophorus maculatus
#=GS M4B034/557-720      DE Uncharacterized protein
#=GS M4B034/557-720      DR GENE3D; 7e1b59ea61a9b6954a868b415cfa4f2e/557-720; 
#=GS M4B034/557-720      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Atherinomorphae; Cyprinodontiformes; Cyprinodontoidei; Poeciliidae; Poeciliinae; Xiphophorus; Xiphophorus maculatus; 
#=GS F6TCH4/538-848      AC F6TCH4
#=GS F6TCH4/538-848      OS Macaca mulatta
#=GS F6TCH4/538-848      DE Leucine-rich repeat-containing protein 8D
#=GS F6TCH4/538-848      DR GENE3D; 904144a19b700eb8eaee3f1ee4544423/538-848; 
#=GS F6TCH4/538-848      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca mulatta; 
#=GS G7NTM8/538-848      AC G7NTM8
#=GS G7NTM8/538-848      OS Macaca fascicularis
#=GS G7NTM8/538-848      DE Putative uncharacterized protein
#=GS G7NTM8/538-848      DR GENE3D; 904144a19b700eb8eaee3f1ee4544423/538-848; 
#=GS G7NTM8/538-848      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca fascicularis; 
#=GS A0A096N8P5/538-848  AC A0A096N8P5
#=GS A0A096N8P5/538-848  OS Papio anubis
#=GS A0A096N8P5/538-848  DE Uncharacterized protein
#=GS A0A096N8P5/538-848  DR GENE3D; 904144a19b700eb8eaee3f1ee4544423/538-848; 
#=GS A0A096N8P5/538-848  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Papio; Papio anubis; 
#=GS A0A0S7IRN9/1-218    AC A0A0S7IRN9
#=GS A0A0S7IRN9/1-218    OS Poeciliopsis prolifica
#=GS A0A0S7IRN9/1-218    DE LRC8D
#=GS A0A0S7IRN9/1-218    DR GENE3D; 968997d47c24aa43221d1608d8c02e6c/1-218; 
#=GS A0A0S7IRN9/1-218    DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Atherinomorphae; Cyprinodontiformes; Cyprinodontoidei; Poeciliidae; Poeciliinae; Poeciliopsis; Poeciliopsis prolifica; 
#=GS G3NK73/608-730      AC G3NK73
#=GS G3NK73/608-730      OS Gasterosteus aculeatus
#=GS G3NK73/608-730      DE Uncharacterized protein
#=GS G3NK73/608-730      DR GENE3D; 98f5d821886b6e5afe242578d1940a9a/608-730; 
#=GS G3NK73/608-730      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; Gasterosteus; Gasterosteus aculeatus; 
#=GS A0A093HRE0/631-762  AC A0A093HRE0
#=GS A0A093HRE0/631-762  OS Struthio camelus australis
#=GS A0A093HRE0/631-762  DE Leucine-rich repeat-containing protein 8D
#=GS A0A093HRE0/631-762  DR GENE3D; abd6d2601b3693b36f98ef0d1b541239/631-762; 
#=GS A0A093HRE0/631-762  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Aves; Palaeognathae; Struthioniformes; Struthionidae; Struthio; Struthio camelus; Struthio camelus australis; 
#=GF TC 23.4 1.1E-08
#=GF SQ 20
Q7L1W4/631-832              ---------------------------------------------------------------------------------------------LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVED----------------
Q5U308/631-839              ---------------------------------------------------------------------------------------------LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNSIRTIEEIISFQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDVLPKQLFKCVKLRTLNLGQNCIASLPEKISQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDQLFDTLP---------
F7GUR8/631-832              ---------------------------------------------------------------------------------------------LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVED----------------
H2LAC6/586-711              ------------------------------------------------------------------------------------GTKLVVLNSLKKMANLAELELHNCELERIPHAIFSLNNLQELDLKSNNIRTIEEVISFQHLKRLTCLKLWYNKIIAIPLSISHVKNLESLYLSHNKLESLPSPLFTLLKLRYLDVSHNCIAVIPPE-----------------------------------------------------------------------------------------------------
T1DB05/631-843              ---------------------------------------------------------------------------------------------LKKMMNVGELELQNCELERIPHAIFSLTNLQELDLKSNNIRTIEEVISFQHLKRLTCLKLWHNKIVNIPSSITHVKNLESLYLSNNKLESLPVAVFSLQKLRCLDVSYNSIAVIPVEIGLLQNLQHLLITGNKVDILPKQLFKCSKLRTLSLGQNCITSIPEKIGQLLQLTNLELKGNCLDRLPATLGQCRLLRKSGLIVEDHLFDTLPSEVK-----
J3SCJ6/631-843              ---------------------------------------------------------------------------------------------LKKMMNVGELELQNCELERIPHAIFSLTNLQELDLKSNNIRTIEEVISFQHLKRLTCLKLWHNKIVNIPSSITHVKNLESLYLSNNKLESLPVAVFSLQKLRCLDVSYNSIAVIPVEIGLLQNLQHLLITGNKVDILPKQLFKCSKLRTLSLGQNCITSIPEKIGQLLQLTNLELKGNCLDRLPATLGQCRLLRKSGLIVEDHLFDTLPSEVK-----
W5U703/545-737              --------------------------------SLNSEHNKMIGLESLKDLRHLKVLYLKSNLSKTPTNLTDLSPHLIKLVVHNDGTKLLVLNSLKKMTSLRELELHHCDLERIPDAIFNLTNLQDLDMKSNNFRTIEEVIRFQHLKRLTCLKLWHNKIVSIPSNINLMKNLESLYLSYNKLETLPAALFHMPKLRYLDLGNNSIALIPDDVEFLHNLQHFDITGN--------------------------------------------------------------------------------------
W5LU14/589-731              --------------------------------------------------------------NKIPTNLAELSPHLVKLVVHNDGTKMVVLNSLKKMANLVELELHNCDLERIPHAIFSLINLQELDLKSNSIRTIEEIISFQHLKRLTCLKLWHNRIIAIPQSISQVKNMEILHLSYNKLETLPAALFYLPKLRHLDLSHNSIL----------------------------------------------------------------------------------------------------------
A0A0H2UHA3/633-841          ---------------------------------------------------------------------------------------------LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNSIRTIEEIISFQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDVLPKQLFKCVKLRTLNLGQNCIASLPEKISQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDQLFDTLP---------
F6Z951/598-731              ------------------------------------------------------------NLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKL---------------------------------------------------------------------------------------------------------------------
G1KUQ0/633-847              ---------------------------------------------------------------------------------------------LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNSIRTIEEVISFQHLKRLTCLKLWHNKIVNIPPSITHVKNLESLYLSNNKLESLPAAVFSLQKLRCLDVSYNSIAVIPVEVGLLQNLQHFHVTGNKVDILPKQLFKCTKLRTLSLGQNCITSIPEKIGQLLQLTHLELKGNCLDRLPPTLGLCRLLRKSGLIVEDHLFDTLPSEVKEA---
L5K4Q3/669-868              ---------------------------------------------------------------------------------------------LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDSLPKQLFKCVKLRTLNLGQNCITSLPEKIGQLSQLTQLELKGNCLDRLPAQLGQCRLLKKSGLIV------------------
A0A091IFX2/621-736          ------------------------------------------------------------------------------------GTKLVVLNSLKKMINVAELELQNCELERIPHAIFSLSNLQELDLKSNSIRTIEEIISFQHLKRLTCLKLWHNKIVEIPPSITHVRNLESLYLSNNKLESLPPAVFSLQKLRCLDVS---------------------------------------------------------------------------------------------------------------
M4B034/557-720              ---------------------------------LNSENNKLIGLESLRDLRHLKILHLKSNLTKIPTNITDLSPHLVRLVIHNDGTKLLVLNTLKKMINLAELELHNCELERIPHAIFSLNNLQELDLKSNNIRTIEEVISFQHLKRLTCLKLWYNKIISIPLSISHVKNLESLYLSHNKLESLPSPLFTLLKLRYL------------------------------------------------------------------------------------------------------------------
F6TCH4/538-848              HLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDSLPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQ
G7NTM8/538-848              HLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDSLPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQ
A0A096N8P5/538-848          HLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDSLPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQ
A0A0S7IRN9/1-218            --------------------------------------------------------------------------HLVRLVIHNDGTKLLVLNTLKKMINLAELELHNCELERIPHAIFSLNNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWYNKIISIPLSISHVKNLESLYLSHNKLESLPAPLFTLLKLRYLDLSHNSVAVIPPEVGFLQNLQHFAITGNKVEVVPKQMFKCVKLRTLCLGHNCITSIPEKIGHLSQLTHLELKGNCLDRLPVQLGHCSLLNRSCLL-------------------
G3NK73/608-730              ------------------------------------------------------------------------------------GTKLLVLNSLKKMLNLAELELLNCELERIPHAIFSLNNLQELDLKSNNIRTIEEIISFQHLKRLTSLKLWHNKIISVPVSISHVKNLEWLYLSHNKLESLPSSLFTLLKLRYLDVSHNSIAVI--------------------------------------------------------------------------------------------------------
A0A093HRE0/631-762          -----------------------------------------------------------------------------------------------KMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNSIRTIEEIISFQHLKRLTCLKLWHNKIVNIPSSITHVKNLESLYLSNNKLESLPAAVFSLQKLRCLDVSYNSIAVIPVEIGLLQNLQHFHITGNKV------------------------------------------------------------------------------------
#=GC scorecons              00000000000000000000000000000000000000000000000000000000000000010101011001110111111133332333288995866999968989999989998959998998999689999979899999999899997989748948967889897986969999799566958599757656453533542433333333322333322212222222212222212222222212221222122212222222222221122122121222212110111111000000000
#=GC scorecons_70           _____________________________________________________________________________________________****_**********************_**************************************_**_**_***********_*******_***_*_***_**_________________________________________________________________________________________________________________
#=GC scorecons_80           _____________________________________________________________________________________________****_*__****_**************_**********_***************************_**_**_*********_*_*******___*_*_***_*__________________________________________________________________________________________________________________
#=GC scorecons_90           _______________________________________________________________________________________________**_*__****_**************_**********_******_***************_***__**_**__*****_**_*_****_**___*_*_**_____________________________________________________________________________________________________________________
//