# STOCKHOLM 1.0 #=GF ID 3.80.10.10/FF/105441 #=GF DE MHC class II transactivator #=GF AC 3.80.10.10/FF/105441 #=GF TP FunFam #=GF DR CATH: 4.2 #=GF DR DOPS: 45.227 #=GS P33076/957-1126 AC P33076 #=GS P33076/957-1126 OS Homo sapiens #=GS P33076/957-1126 DE MHC class II transactivator #=GS P33076/957-1126 DR GENE3D; 1dbf6346758ec00cb648baf3e8f1fabe/957-1126; #=GS P33076/957-1126 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS P33076/957-1126 DR GO; GO:0000122; GO:0003713; GO:0005515; GO:0005654; GO:0006955; GO:0008022; GO:0016605; GO:0032403; GO:0032966; GO:0033613; GO:0034341; GO:0044212; GO:0045345; GO:0045348; GO:0045892; GO:0045893; GO:0045944; GO:0046677; GO:0060333; #=GS P33076/957-1126 DR EC; 2.7.11.1; #=GS A0A0B4J1S1/957-1126 AC A0A0B4J1S1 #=GS A0A0B4J1S1/957-1126 OS Homo sapiens #=GS A0A0B4J1S1/957-1126 DE MHC class II transactivator #=GS A0A0B4J1S1/957-1126 DR GENE3D; 4ca6b047fd6da19422c2e3ef45a28c08/957-1126; #=GS A0A0B4J1S1/957-1126 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS A0A087X2I7/958-1127 AC A0A087X2I7 #=GS A0A087X2I7/958-1127 OS Homo sapiens #=GS A0A087X2I7/958-1127 DE MHC class II transactivator #=GS A0A087X2I7/958-1127 DR GENE3D; b953d072a414c8ec8d8f56b8464c2943/958-1127; #=GS A0A087X2I7/958-1127 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS G3V6C0/854-1151 AC G3V6C0 #=GS G3V6C0/854-1151 OS Rattus norvegicus #=GS G3V6C0/854-1151 DE Class II, major histocompatibility complex, transactivator #=GS G3V6C0/854-1151 DR GENE3D; 83dd1c71eed5629d26a43ea5ccee9252/854-1151; #=GS G3V6C0/854-1151 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Rodentia; Myomorpha; Muridae; Murinae; Rattus; Rattus norvegicus; #=GS G3V6C0/854-1151 DR GO; GO:0000122; GO:0006954; GO:0007568; GO:0009986; GO:0045348; GO:0045944; GO:0071257; GO:0071346; GO:0071360; #=GS A0A0G2JVN3/877-1045 AC A0A0G2JVN3 #=GS A0A0G2JVN3/877-1045 OS Rattus norvegicus #=GS A0A0G2JVN3/877-1045 DE Class II, major histocompatibility complex, transactivator #=GS A0A0G2JVN3/877-1045 DR GENE3D; d0888f242a784b2076be54938b69ce25/877-1045; #=GS A0A0G2JVN3/877-1045 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Rodentia; Myomorpha; Muridae; Murinae; Rattus; Rattus norvegicus; #=GS A0A0G2JVN3/877-1045 DR GO; GO:0000122; GO:0006954; GO:0007568; GO:0009986; GO:0045348; GO:0045944; GO:0071257; GO:0071346; GO:0071360; #=GS A0A0G2K9Q5/910-1066 AC A0A0G2K9Q5 #=GS A0A0G2K9Q5/910-1066 OS Rattus norvegicus #=GS A0A0G2K9Q5/910-1066 DE Class II, major histocompatibility complex, transactivator #=GS A0A0G2K9Q5/910-1066 DR GENE3D; f04466a9dca033ad768058e2027f9f01/910-1066; #=GS A0A0G2K9Q5/910-1066 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Rodentia; Myomorpha; Muridae; Murinae; Rattus; Rattus norvegicus; #=GS A0A0G2K9Q5/910-1066 DR GO; GO:0000122; GO:0006954; GO:0007568; GO:0009986; GO:0045348; GO:0045944; GO:0071257; GO:0071346; GO:0071360; #=GS F6S719/371-542 AC F6S719 #=GS F6S719/371-542 OS Macaca mulatta #=GS F6S719/371-542 DE Uncharacterized protein #=GS F6S719/371-542 DR GENE3D; 12c65c866df222d8ed6067c8dba37bba/371-542; #=GS F6S719/371-542 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca mulatta; #=GS F6S727/955-1126 AC F6S727 #=GS F6S727/955-1126 OS Macaca mulatta #=GS F6S727/955-1126 DE Uncharacterized protein #=GS F6S727/955-1126 DR GENE3D; 23dfb5d1cf5c94a06f7a7fad1c2e2828/955-1126; #=GS F6S727/955-1126 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca mulatta; #=GS F7IRG7/780-882_951-1121 AC F7IRG7 #=GS F7IRG7/780-882_951-1121 OS Callithrix jacchus #=GS F7IRG7/780-882_951-1121 DE Uncharacterized protein #=GS F7IRG7/780-882_951-1121 DR GENE3D; 243d61638bac20bc6a1223a02d199e0d/780-882_951-1121; #=GS F7IRG7/780-882_951-1121 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix; Callithrix jacchus; #=GS H2NQ45/939-1123 AC H2NQ45 #=GS H2NQ45/939-1123 OS Pongo abelii #=GS H2NQ45/939-1123 DE Uncharacterized protein #=GS H2NQ45/939-1123 DR GENE3D; 83d6ef2124ae19c0b155a1f4b4a4f578/939-1123; #=GS H2NQ45/939-1123 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Ponginae; Pongo; Pongo abelii; #=GS A0A0D9R7V0/763-857_926-1089 AC A0A0D9R7V0 #=GS A0A0D9R7V0/763-857_926-1089 OS Chlorocebus sabaeus #=GS A0A0D9R7V0/763-857_926-1089 DE Uncharacterized protein #=GS A0A0D9R7V0/763-857_926-1089 DR GENE3D; 88a77a5333a83b90d3b4717689076ed5/763-857_926-1089; #=GS A0A0D9R7V0/763-857_926-1089 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Chlorocebus; Chlorocebus sabaeus; #=GS G7Q0H3/779-881_950-1112 AC G7Q0H3 #=GS G7Q0H3/779-881_950-1112 OS Macaca fascicularis #=GS G7Q0H3/779-881_950-1112 DE MHC class II transactivator #=GS G7Q0H3/779-881_950-1112 DR GENE3D; bb9817eca44a5f114772bee9186b9288/779-881_950-1112; #=GS G7Q0H3/779-881_950-1112 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca fascicularis; #=GS H2QAK4/957-1126 AC H2QAK4 #=GS H2QAK4/957-1126 OS Pan troglodytes #=GS H2QAK4/957-1126 DE Uncharacterized protein #=GS H2QAK4/957-1126 DR GENE3D; bc811141cc0b8dec067e6db4320bb5b2/957-1126; #=GS H2QAK4/957-1126 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Pan; Pan troglodytes; #=GS H0X7L9/849-907_976-1139 AC H0X7L9 #=GS H0X7L9/849-907_976-1139 OS Otolemur garnettii #=GS H0X7L9/849-907_976-1139 DE Uncharacterized protein #=GS H0X7L9/849-907_976-1139 DR GENE3D; bd98d664370a66379e3af47b80139794/849-907_976-1139; #=GS H0X7L9/849-907_976-1139 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes; Galagidae; Otolemur; Otolemur garnettii; #=GS G3RDU5/931-1103 AC G3RDU5 #=GS G3RDU5/931-1103 OS Gorilla gorilla gorilla #=GS G3RDU5/931-1103 DE Uncharacterized protein #=GS G3RDU5/931-1103 DR GENE3D; e44664ad0a047e4e45419331428e36c3/931-1103; #=GS G3RDU5/931-1103 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Gorilla; Gorilla gorilla; Gorilla gorilla gorilla; #=GS A0A096NLN9/780-882_951-1114 AC A0A096NLN9 #=GS A0A096NLN9/780-882_951-1114 OS Papio anubis #=GS A0A096NLN9/780-882_951-1114 DE Uncharacterized protein #=GS A0A096NLN9/780-882_951-1114 DR GENE3D; ef0d2a25d4e4b59003d8b78938e37128/780-882_951-1114; #=GS A0A096NLN9/780-882_951-1114 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Papio; Papio anubis; #=GS G1RGL7/782-880_949-1112 AC G1RGL7 #=GS G1RGL7/782-880_949-1112 OS Nomascus leucogenys #=GS G1RGL7/782-880_949-1112 DE Uncharacterized protein #=GS G1RGL7/782-880_949-1112 DR GENE3D; f245598dec28c61f01bdfae033b4668d/782-880_949-1112; #=GS G1RGL7/782-880_949-1112 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hylobatidae; Nomascus; Nomascus leucogenys; #=GS F6VTY4/364-544 AC F6VTY4 #=GS F6VTY4/364-544 OS Callithrix jacchus #=GS F6VTY4/364-544 DE Uncharacterized protein #=GS F6VTY4/364-544 DR GENE3D; f7906dde4fcdb0f0ab535fe7fc73925e/364-544; #=GS F6VTY4/364-544 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix; Callithrix jacchus; #=GS F7CVK8/956-1127 AC F7CVK8 #=GS F7CVK8/956-1127 OS Macaca mulatta #=GS F7CVK8/956-1127 DE Uncharacterized protein #=GS F7CVK8/956-1127 DR GENE3D; fec5e89c9c3719bd5d8e7bec19c8d79c/956-1127; #=GS F7CVK8/956-1127 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca mulatta; #=GF TC 366.6 1.1E-113 #=GF SQ 19 P33076/957-1126 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSR-- A0A0B4J1S1/957-1126 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSR-- A0A087X2I7/958-1127 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSR-- G3V6C0/854-1151 ----------------------------------------------------GHLSFLGTRLTAPDVYVLGRALETASQDFSLDLRQTGIEPSRLGDLVGLSCVTSFRASLSDTMALWESLQHQGETQLLQAAEEKFTIEPFKAKSPKDVEDLDSLVQTQRLRNPSADAAKDLPAIRDLKKLEFALGPVLGPQAFPTLAKILPAFSSLQHLDLDSLSENKIGDKGVSKLSATFPQLKALETLNLSQNSITDVGACKLAEALPALAKSLLRLSLYNNCICDEGAKSLARVLPDMVSLRVMDVQFNKFTAVGAQQLTSSLQKCPQVETLAMWTPTIPFGVQEHLQQLDARIS A0A0G2JVN3/877-1045 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDLKKLEFALGPVLGPQAFPTLAKILPAFSSLQHLDLDSLSENKIGDKGVSKLSATFPQLKALETLNLSQNSITDVGACKLAEALPALAKSLLRLSLYNNCICDEGAKSLARVLPDMVSLRVMDVQFNKFTAVGAQQLTSSLQKCPQVETLAMWTPTIPFGVQEHLQQL----- A0A0G2K9Q5/910-1066 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLGPQAFPTLAKILPAFSSLQHLDLDSLSENKIGDKGVSKLSATFPQLKALETLNLSQNSITDVGACKLAEALPALAKSLLRLSLYNNCICDEGAKSLARVLPDMVSLRVMDVQFNKFTAVGAQQLTSSLQKCPQVETLAMWTPTIPFGVQEHLQQL----- F6S719/371-542 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDLKKLEFALGPISGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNSITDLGAYKLAEGLPSLAASLLRLSLYNNCICDMGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRKCPHVETLAMWTPTIPFSVQEHLQQQDSR-- F6S727/955-1126 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDLKKLEFALGPISGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNSITDLGAYKLAEGLPSLAASLLRLSLYNNCICDMGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRKCPHVETLAMWTPTIPFSVQEHLQQQDSR-- F7IRG7/780-882_951-1121 AALADKKQKVLAKYLKRLQPGTLRARQLLELLHCAHEAEEAGIWRHVVQELPARLSFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGIDPSGLGSLVGLSC--------------------------------------------------------------------ELPAVRDLKKLEFALGPVSGPRAFPKLVRILVAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNSITDVGACKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRKCPHVETLAMWTPTIPFSVQEHL-------- H2NQ45/939-1123 ------------------------------------------------------------------------------------TRSSSEDTAG-----------------------------------------------------------------------------ELPAVRDLKKLEFALGPISGPQAFPKLVQILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQD---- A0A0D9R7V0/763-857_926-1089 --------KVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPARLSFLGTRLMPPDAHVLGKALEAAGQDFSLDLRSTGIDPSGLGSLVGLSC--------------------------------------------------------------------ELPAVRDLKKLEFALGPISGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNSITDLGAYKLAEGLPSLAASLLRLSLYNNCICDMGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRKCPHVETLAMWTPTIP--------------- G7Q0H3/779-881_950-1112 TAFADRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPARLSFLGTRLTPPDAHVLGKALEAAGQDFALDLRNTGIDPSGLGSLVGLSC--------------------------------------------------------------------ELPAVRDLKKLEFALGPISGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNSITDLGAYKLAEGLPSLAASLLRLSLYNNCICDMGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRKCPHVETLAMWTPTI---------------- H2QAK4/957-1126 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSR-- H0X7L9/849-907_976-1139 --------------------------------------------QHVVQELPARLSFLGTRLTPPDAHVLGRALEAAGQDFSLDLCNTGIDPSGLGSLVGLSC--------------------------------------------------------------------ELPAVRDLKKLEFALGPISGPQAFPRLVRILPAFSSLQHLDLDSPSENKIGDEGVAQLSAIFPQLKTLETLNLSQNSITDVGACKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRMMDVQYNKFTAAGAQQLAASLRKCPHVKTLAMWTPTIP--------------- G3RDU5/931-1103 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VRDLKKLEFALGPISGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDDGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDMGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSR-- A0A096NLN9/780-882_951-1114 TALADRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPARLSFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGIDPSGLGSLVGLSC--------------------------------------------------------------------ELPAVRDLKKLEFALGPISGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNSITDLGAYKLAEGLPSLAASLLRLSLYNNCICDMGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRKCPHVETLAMWTPTIP--------------- G1RGL7/782-880_949-1112 ATEAEGA----CEVLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPACLSFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSC--------------------------------------------------------------------ELPAVRDLKKLEFALGPISGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNSITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIP--------------- F6VTY4/364-544 -------------------------------------------------------------------------------------------TAG-----------------------------------------------------------------------------ELPAVRDLKKLEFALGPVSGPRAFPKLVRILVAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNSITDVGACKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRKCPHVETLAMWTPTIPFSVQEHLQQQDSRI- F7CVK8/956-1127 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDLKKLEFALGPISGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNSITDLGAYKLAEGLPSLAASLLRLSLYNNCICDMGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRKCPHVETLAMWTPTIPFSVQEHLQQQDSR-- #=GC scorecons 00000000000000000000000000000000000000000000111111111111111111111111111111111111111121122212221111111110000000000000000000000000000000000000000000000000000000000000000000022222557777777777769989996977995999999999996899999996998799989999969999999996999699699996997996999999999999994997999999999999989999799999799999779977997989999999997323333333121100 #=GC scorecons_70 __________________________________________________________________________________________________________________________________________________________________________________************************_*****************************************************************************_******************************************************_______________ #=GC scorecons_80 __________________________________________________________________________________________________________________________________________________________________________________**********__******_*_***_***********_********_*************_*********_***_**_****_**_**_**************_**_************************_******_*******************_______________ #=GC scorecons_90 ______________________________________________________________________________________________________________________________________________________________________________________________**_***_*__**_***********_********_***_*********_*********_***_**_****_**_**_**************_**_******************_*****_*****__**__**_***********________________ //