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CATH Superfamily 3.50.80.10

D-tyrosyl-tRNA(Tyr) deacylase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: D-tyrosyl-tRNA(Tyr) deacylase

Structural domains comprising this superfamily share the structure of D-tyrosyl-tRNA(Tyr) deacylase (DTD), also known as D-aminoacyl-tRNA deacylase, an editing enzyme that removes D-amino acids from mischarged tRNAs. Structural studies have shown various different modes of D-amino acid recognition by DTDs, suggesting an inherent plasticity that can accommodate all d-amino acids. DTDs are essentially inactive toward L-aa-tRNAs PMID:20007323,PMID:20445234.

This enzymes provide a very accurate proofreading mechanism which enforces high fidelity during translation of the genetic code PMID:261130360.

GO Diversity

Unique GO annotations
21 Unique GO terms

EC Diversity

Unique EC annotations
5 Unique EC terms

Species Diversity

Unique species annotations
11003 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 161
Domain clusters (>95% seq id): 10
Domain clusters (>35% seq id): 4
Unique PDBs: 54
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 3
Function
Unique EC: 5
Unique GO: 21
Taxonomy
Unique Species: 11003