The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
DD-peptidase/beta-lactamase superfamily
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22236: Glutaminase kidney isoform, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutaminase activity GO:0004359
Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
14 A0A0B4LF95 (/ISS) A0A0B4LGA3 (/ISS) A1Z942 (/ISS) A1Z943 (/ISS) A1Z944 (/ISS) E1JH47 (/ISS) P13264 (/ISS) Q0E9A1 (/ISS) Q1RL13 (/ISS) Q7JQK6 (/ISS)
(4 more)
Glutaminase activity GO:0004359
Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
5 D3Z7P3 (/IDA) O94925 (/IDA) P0A6W0 (/IDA) P77454 (/IDA) Q66V97 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 D3Z7P3 (/IPI) O94925 (/IPI) P13264 (/IPI) Q9UI32 (/IPI)
Glutaminase activity GO:0004359
Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
3 O94925 (/TAS) P13264 (/TAS) Q9UI32 (/TAS)
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
1 Q9KUR1 (/ISS)
Glutaminase activity GO:0004359
Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
1 D3Z7P3 (/IMP)
Glutaminase activity GO:0004359
Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
1 D3Z7P3 (/ISO)
Glutaminase activity GO:0004359
Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
1 O94925 (/NAS)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutamine metabolic process GO:0006541
The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
10 A0A0B4LF95 (/ISS) A0A0B4LGA3 (/ISS) A1Z942 (/ISS) A1Z943 (/ISS) A1Z944 (/ISS) E1JH47 (/ISS) Q0E9A1 (/ISS) Q1RL13 (/ISS) Q7JQK6 (/ISS) Q961I1 (/ISS)
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
2 D3Z7P3 (/IDA) O94925 (/IDA)
Glutamine catabolic process GO:0006543
The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid.
2 D3Z7P3 (/IDA) O94925 (/IDA)
Glutamine catabolic process GO:0006543
The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid.
2 D3Z7P3 (/IMP) P0A6W0 (/IMP)
Cellular amino acid biosynthetic process GO:0008652
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
2 O94925 (/TAS) Q9UI32 (/TAS)
Glutamate secretion GO:0014047
The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system.
2 O94925 (/TAS) Q9UI32 (/TAS)
Negative regulation of growth GO:0045926
Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.
2 P0A6W0 (/IMP) P77454 (/IMP)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
2 D3Z7P3 (/IDA) O94925 (/IDA)
Suckling behavior GO:0001967
Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast.
1 D3Z7P3 (/IMP)
Regulation of respiratory gaseous exchange by neurological system process GO:0002087
A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.
1 D3Z7P3 (/IMP)
Cellular amino acid metabolic process GO:0006520
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
1 Q9UI32 (/TAS)
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
1 D3Z7P3 (/ISO)
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
1 P13264 (/ISS)
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
1 O94925 (/TAS)
Glutamine metabolic process GO:0006541
The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
1 Q66V97 (/IDA)
Glutamine catabolic process GO:0006543
The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid.
1 D3Z7P3 (/ISO)
Glutamine catabolic process GO:0006543
The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid.
1 P13264 (/ISS)
Glutamine catabolic process GO:0006543
The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid.
1 O94925 (/NAS)
Glutamine catabolic process GO:0006543
The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid.
1 P13264 (/TAS)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a neuron, across a chemical synapse, the subsequent activation of neurotransmitter receptors of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 D3Z7P3 (/IMP)
Response to acidic pH GO:0010447
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
1 P77454 (/IEP)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 Q9UI32 (/IMP)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 Q571F8 (/ISO)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 D3Z7P3 (/ISO)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 P13264 (/ISS)
Reactive oxygen species metabolic process GO:0072593
The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
1 Q9UI32 (/IMP)
Reactive oxygen species metabolic process GO:0072593
The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
1 Q571F8 (/ISO)
Positive regulation of protein targeting to mitochondrion GO:1903955
Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.
1 Q9UI32 (/IMP)
Positive regulation of protein targeting to mitochondrion GO:1903955
Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.
1 Q571F8 (/ISO)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
12 A0A0B4LF95 (/ISS) A0A0B4LGA3 (/ISS) A1Z942 (/ISS) A1Z943 (/ISS) A1Z944 (/ISS) E1JH47 (/ISS) Q0E9A1 (/ISS) Q19013 (/ISS) Q1RL13 (/ISS) Q7JQK6 (/ISS)
(2 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 O94925 (/IDA) P13264 (/IDA) Q571F8 (/IDA) Q9UI32 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
3 O94925 (/TAS) P28492 (/TAS) Q9UI32 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 D3Z7P3 (/ISO) Q571F8 (/ISO)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P9WK67 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 O94925 (/NAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9UI32 (/TAS)