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CATH Superfamily 3.40.630.10

Zn peptidases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Zn peptidases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 34828: Glutamate carboxypeptidase 2 homolog

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glutamate carboxypeptidase II. [EC: 3.4.17.21]
Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.
  • Hydrolyzes alpha-peptide bonds in Ac-Asp-Glu, Asp-Glu, and Glu-Glu, but also gamma-glutamyl bonds in gamma-Glu-Glu and folylpoly-gamma- glutamates.
  • With folylpoly-gamma-glutamates, shows processive carboxypeptidase activity to produce pteroylmonoglutamate.
  • Does not hydrolyze Ac-beta-Asp-Glu.
  • Inhibited by quisqualic acid, Ac-beta-Asp-Glu, and 2-phosphonomethyl- pentanedioate.
  • The release of C-terminal glutamate from folylpoly-gamma-glutamates is also catalyzed by EC 3.4.17.11 and EC 3.4.19.9.
  • Belongs to peptidase family M28.
  • Formerly EC 3.4.19.8.
 52 A0A061IDC0 A0A061IEA8 A0A0B2QQZ6 A0A0B2QRR5 A0A0B2S7Y3 A0A0B2SGW6 A0A0F4YN19 A0A0F8D9D6 A0A0P7Z341 A0A0P8AM62
(42 more...)
2-alkenal reductase (NAD(P)(+)). [EC: 1.3.1.74]
A n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H.
  • Highly specific for 4-hydroxynon-2-enal and non-2-enal.
  • Alk-2-enals of shorter chain have lower affinities.
  • Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one.
  • Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid.
  • Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones (cf. EC 1.3.1.102).
 2 B9RKG5 B9SDP7
Aminopeptidase S. [EC: 3.4.11.24]
Release of an N-terminal amino acid with a preference for large hydrophobic amino-terminus residues.
  • Activated by Ca(2+).
  • In the presence of Ca(2+), the best substrates are Leu-Phe, Leu-Ser, Leu-pNA (aminoacyl-p-nitroanilide), Phe-Phe-Phe and Phe-Phe.
  • Peptides with proline in the P1' position are not substrates.
  • Belongs to peptidase family M28.
  • Formerly EC 3.4.11.n1.
 1 A0A142YBX9
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